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Preheat oven to 350 degrees.
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Set up your cupcake pan with liners.
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Using a medium bowl, whisk flour, baking powder, salt, and baking soda.
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In a separate large mixing bowl, beat butter with an electric mixer or Kitchenaid on medium to high for 30 seconds.
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Now add sugar, caramel and vanilla to the butter and beat until combined.
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Add egg whites, and eggs one at a time, beating well after each addition.
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Alternate, the flour mixture and milk to butter mixture, beating on low speed until everything is well mixed together.
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Fill the cupcake pan liners 2/3 with cake batter.
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Bake for 18-20 minutes.
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Remove cupcakes from pan and allow to cool on a wire rack for 30 minutes before frosting.